Fresh analysis suggests that people who come off blockbuster weight-loss injections like Mounjaro or Wegovy may regain lost weight much more quickly than those who halt traditional lifestyle plans.
Findings released in a prominent medical journal demonstrates that while overweight individuals can lose about a fifth of their body weight while undergoing treatment, the mass comes back at an estimated rate of 0.8 kg per month after stopping.
"People purchasing these drugs should be cognizant of the danger of quick rebound weight gain when the medication ends," stated expert Dr. Susan Jebb.
That rate of regain implies a return to pre-treatment weight within about 18 months.
Comparing Therapies
The analysis, which reviewed 37 of studies involving over 9,000 of patients, compared the effects of these new drugs with other pills.
Scientists note that individuals who shed pounds through diet and exercise usually have a more gradual creep back—perhaps 100 grams monthly—once they finish.
Explaining the Quick Regain
Experts propose the mechanism of the drugs is key to understanding the amplified weight return.
The injections copy a natural hormone called glucagon-like peptide-1, which controls appetite.
"Artificially providing GLP-1 levels far above than the body's typical production may cause the system to produce less of its endogenous hormone, and may also diminish responsiveness to its actions," noted Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication means hunger is unsuppressed, making excessive eating much more probable."
A Lifelong Issue?
The NHS recommend the jabs for people with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
A number of clinicians argue that, given the significant potential of weight regain, the therapy might need to be life-long.
This opinion is supported by drug manufacturers, who note that the findings "emphasize the persistent nature of obesity," comparing it to managing diseases like high blood pressure.
Patient Experiences
Users who have stopped the jabs explain a powerful return of hunger.
"It was like a trigger flipping and you become starving," recalled an individual.
The struggle is exacerbated if individuals have not adopted sustainable dietary or behavioural modifications during therapy.
Growing Interest
Recent estimates show that a significant number of people in the UK have tried weight-loss jabs in the past year, with demand continuing to grow.
- Use is higher among females compared to males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than the NHS.
In conclusion, researchers stress that while the jabs are potent tools for weight loss, they are not a standalone cure and maintained weight loss hinges on ongoing behavioural changes.
